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Abstract
The development of new separation techniques and different mass spectrometry instrumental devices, as well as the great availability of specific reactants, offers ample choice to scientists for carrying out high-throughput proteomic studies and being competitive in the field today. However, the different options available often do not provide comparable results, which can be linked to factors such as the strategy adopted, the nature of the sample and the instrumental availability. In this critical review, the results obtained so far in the study of human saliva by different proteomic approaches will be compared and discussed.
Financial & competing interests disclosure
The authors acknowledge the financial support of Nando Peretti Foundation, MIUR, Telethon, Università di Cagliari, Università Cattolica in Rome, Italian National Research Council, Regione Sardegna and International Scientific Institute ‘Paolo VI’. The authors thank their programs of scientific research promotion and diffusion. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.