High-dose chemotherapy and stem cell rescue for high-risk Ewing’s family of tumors

Abstract

The prognosis for high-risk Ewing’s tumors has been improved by multimodal radiation and chemotherapy. Ewing’s family of tumors requires risk-adapted treatment. Risk stratification is dependent on stage, tumor localization and volume, and the pattern of disease spread at the time of diagnosis and the time of relapse. The concepts for high-dose therapy followed by hematopoietic cell transplantation in Ewing’s family of tumors are based on dose–response and dose–intensity relationships. This article will discuss the use of high-dose therapy followed by hematopoietic cell transplantation, focusing on recent progress with respect to agent combinations, dose and outcomes of therapy.

Keywords::

• Ewing’s sarcoma
• hematopoietic stem cell transplant
• high-dose therapy

Financial & competing interests disclosure

The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.

No writing assistance was utilized in the production of this manuscript.