Current role of myeloperoxidase in routine clinical practice

Abstract

Recognition of inflammation as a critical contributor to atherothrombosis has led to the pursuit of new approaches for the diagnosis and treatment of patients with coronary heart disease. As the intricate relationships between cellular and noncellular participants in the inflammatory aspects of atherogenesis, plaque destabilization and thrombosis have been defined, specific constituents have emerged as potential noninvasive indicators of these processes. Myeloperoxidase is a protein released during degranulation of neutrophils and monocytes. The available experimental and epidemiologic data provide compelling evidence to sustain strong interest in myeloperoxidase as a candidate for clinical application. Nevertheless, additional investigation will be important to fully evaluate myeloperoxidase as a sensitive predictor for myocardial infarction in patients with chest pain.

Keywords::

• acute coronary syndrome
• chest pain
• inflammation
• myeloperoxidase
• myocardial infarction

Financial & competing interests disclosure

All authors confirmed they have contributed to the intellectual content of this paper and have met the following three requirements: significant contributions to the conception and design, acquisition of data, or analysis and interpretation of data; drafting or revising the article for intellectual content; and final approval of the published article. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.