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Acknowledgements
A special acknowledgement to M McCusker and M Viveiros for the kind revision of the manuscript as well as for the very precious discussions on this subject.
Financial & competing interests disclosure
The author acknowledges the Fundação para a Ciência e a Tecnologia of Portugal for the financial support given through the years: EU-FSE/FEDER-PTDC/BIA-MIC/105509/2008, EU-FSE/FEDER-PTDC/SAU-FCF/102807/2008, EU-FSE/FEDER-PTDC/BIA-MIC/121859/2010 and SFRH/BPD/63871/2009. The author has no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.
No writing assistance was utilized in the production of this manuscript.