A combination recombinant protein and outer membrane vesicle vaccine against serogroup B meningococcal disease

Abstract

Although meningococcal disease caused by serogroup B remains an important public health concern, a licensed vaccine providing broad protection against this pathogen is not yet available. Advances in genomics have paved the way for the discovery of new vaccine candidates for inclusion into a multicomponent serogroup B vaccine. In this article, we will review recent advances in the development of these vaccines, focussing particularly on one of the ‘next generation’ MenB vaccines, 4CMenB.

Keywords::

• meningococcal vaccines
• Neisseria meningitidis
• outer membrane vesicle
• recombinant proteins
• serogroup B

Acknowledgements

The authors would like to thank Andrew J Pollard for his helpful comments on this manuscript.

Financial & competing interests disclosure

Matthew D Snape has received financial assistance from Novartis Vaccines to attend conferences, and has had travel and accommodation expenses paid by Novartis Vaccines while working in collaboration with Novartis Vaccines in Siena, Italy. Matthew D Snape is funded by the Oxford Partnership Comprehensive Biomedical Research Centre with funding from the NIHR Biomedical Research Centre Programme, which also provides support to the Oxford Vaccine Group. The authors have no other relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript apart from those disclosed.

No writing assistance was utilized in the production of this manuscript.