Abstract
Calcific aortic stenosis (AS) is a condition that develops as a result of a chronic inflammatory process that leads to valve degeneration. Older adults exhibit an increased prevalence of aortic valvular fibrosis and calcification with associated sclerosis and stenosis. Severe AS requires relief of the obstruction to alleviate symptoms and reduce morbidity and mortality. Surgical aortic valve replacement is an effective therapy for severe AS and has been associated with excellent outcomes in selected octogenarians and nonagenarians. Transcatheter valve replacement is an effective alternative to surgery in patients who are inoperable or who pose a high surgical risk. Optimal management of older adults with severe AS requires a multidisciplinary approach with appropriate consideration of comorbid conditions, frailty and patient preferences.
Financial & competing interests disclosure
The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
No writing assistance was utilized in the production of this manuscript.
Notes
CTA: Computed tomographic angiography.
ADL: Activity of daily living; IADL: Instrumental activity of daily living.