Preventative effect of various fluids used in the epitympanic bulla on deterioration of cochlear function during labyrinthectomy

Abstract

Conclusion: Preventing leakage of endolymph during vestibular destruction may be important in the acute phase. Objectives: Vestibulotomy causes significant decrease in the endocochlear potential (EP). The effect of artificial perilymph and distilled water administration during vestibulotomy on hearing preservation was evaluated in Hartley guinea pigs. Methods: Animals were divided into three groups: the epitympanic bulla was filled with artificial perilymph or distilled water, or was not filled with any solution (control group). The EP and [K⁺] were monitored using double-barrelled ion-selective microelectrodes in the second turn of the cochlea. Results: EP was not significantly different between the artificial perilymph and the distilled water groups, although both groups showed better preservation of EP compared with the control group. The [K⁺] was not significantly different between the three groups.

Keywords::

• Translabyrinth
• vestibule

Acknowledgment

This study was supported by a grant from the Ministry of Education, Culture, Sports, Science and Technology-Japan (Grant-in-Aid for Scientific Research (B) 21390457).

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.