The Effects of Rehabilitative Training on the Behaviors of Parkinson's Disease Mouse and Underlying Mechanism

ABSTRACT

Objective: To examine the effects of rehabilitative training on mice behavior improvement in a 1-Methyl-4-Phenyl-1,2,3,6-Tetrahydropyridine (MPTP) mice model of Parkinson's disease (PD). Methods: MPTP mice model of Parkinson disease was generated. The rehabilitative training included daily running wheel and balance walking; the control group was allowed for free activity. The behaviors of the two groups were investigated at 1 week, 2 weeks, and 4 weeks and the content of dopamine (DA) in striatum of different groups of mice was measured with high-performance liquid chromatography (HPLC). Results: The results showed that as compared to the control group, the score of climbing pole, traction, swimming tests, and dopamine content was improved in the rehabilitative training group. Conclusion: This suggested that rehabilitative training could improve the locomotor ability and dopamine content in PD mouse model.

KEYWORDS: :

• dopamine content
• locomotor
• mice model
• Parkinson
• rehabilitation
• striatum
• training