Association between intercellular adhesion molecule-1 gene K469E polymorphism and the risk of stroke in a Chinese population: a meta-analysis

Abstract

Several epidemiologic studies have evaluated the association between intercellular adhesion molecule-1 (ICAM-1) gene K469E polymorphism and stroke, but the results were inconsistent. The present meta-analysis was performed to investigate the relationship between K469E polymorphism and stroke in the Chinese population. A comprehensive search for related studies from the electronic databases of PubMed, Embase, Web of Science, CBMdisc and CNKI as well as a manual search of the references of identified articles was performed. Data were extracted to calculate for allelic, additive, dominant and recessive models using pooled odds ratios (ORs) along with 95% confidence intervals (CIs) by Review Manager 5.0 and Stata 11.0. Different effect models, subgroup analysis, sensitivity analysis, publication bias and power calculations were used to improve the comprehensive analysis. Finally, a total of 12 studies containing 1593 cases and 1555 controls were included in the final meta-analysis. No evidence of significant association between ICAM-1 gene K469E polymorphism and stroke was found in all four models (allelic model: OR = 1.07, 95%CI = 0.78–1.47; additive model: OR = 1.21, 95% CI = 0.67–2.16 (EE vs. KK); OR = 1.04, 95%CI = 0.75–1.45 (EK vs. KK); dominant model: OR = 1.07, 95% CI = 0.73–1.56; and recessive model: OR = 1.18, 95% CI = 0.77–1.83, respectively) based on the overall population, as well as subgroup analysis and sensitivity analysis. In conclusion, the present meta-analysis showed no evidence of significant association between ICAM-1 gene K469E polymorphism and stroke in the Chinese population. Nonetheless, this conclusion should be interpreted cautiously due to the low statistical power and considerable heterogeneity. Therefore, larger sample-size studies with homogeneous cases and well-matched controls are needed to further address this correlation.

KEYWORDS:

• intercellular adhesion molecule-1
• ICAM-1
• stroke
• gene polymorphism
• meta-analysis

Declaration of Interest

The authors report no conflict of interest. The authors alone are responsible for the content and writing of this paper.

This work was supported by the Natural Science Foundation Project of CQ CSTC (CSTC2012JJJQ10003 to Li-Li Zhang) and the National Natural Science Foundation of China (NSFC 81271282 to Jing-Cheng Li).

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