Occurrence of Hashimoto's thyroiditis among the patients with Sydenham's chorea

Abstract

Aim: The purpose of this study was to examine the possible association of Hashimoto's thyroiditis (HT) with Sydenham's chorea (SC). Materials and Methods: A total of 25 SC patients and 25 patients with the diagnosis of HT were included in the study. Neurological, cardiac, radiological abnormalities, clinical findings, and biochemical analysis were evaluated. Results: Heart murmur as a result of mitral valve deformation was present in all SC group patients. No neurologic and cardiac abnormalities were noted in HT group. Serum thyroid-stimulating hormone (TSH), anti-thyroid peroxidase, and anti-thyroglobulin levels were found to be high in 4 patients of the SC group and called as SC with HT group. Significant elevation of serum TSH levels in SC with HT group (31.75 ± 3.71 μU/ml) was observed when compared to HT group (12.60 ± 4.24 μU/ml, p < 0.05). Conclusion: These results showed that HT can be occured among the patients with SC with cardiac involvement.

KEYWORDS:

• carditis
• chorea
• thyroid-stimulating hormone
• thyroiditis