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International Journal of Neuroscience Volume 126, 2016 - Issue 1
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Original Article

"Clues on Balo's concentric sclerosis evolution from serial analysis of ADC values"

Paolo RipellinoDepartment of Neurology, University of Eastern Piedmont, Novara, ItalyCorrespondence[email protected]
,
Roman KhonsariAPHP –Hôpital Pitié-Salpêtrière, Service de Chirurgie Maxillofaciale et Stomatologie, Paris, France; Sorbonne Universités, UPMC Univ Paris, Paris, France
,
Alessandro SteccoDepartment of Radiology, University of Eastern Piedmont, Novara, Italy
,
Massimo FilippiNeuroimaging Research Unit, Department of Neuroscience, Scientific Institute and University “Vita e Salute”, OSR, Milan, Italy
,
Marco PerchinunnoDepartment of Radiology, University of Eastern Piedmont, Novara, Italy
&
Roberto CantelloDepartment of Neurology, University of Eastern Piedmont, Novara, Italy
Pages 88-95 | Received 21 Oct 2014, Accepted 16 Nov 2014, Published online: 05 Jan 2015
 
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Abstract

Balò's sclerosis is considered a rare variant of multiple sclerosis characterized by demyelination with concentric rings. Advanced magnetic resonance studies allow nowadays early diagnosis and prompt treatment. However, the pathophysiology of lesion evolution is still matter of debate, as detailed in our literature review. Based on a clear-cut Balò's lesion analysis, we describe early changes in DWI and ADC values within the different layers, favoring the concept of a centrifugal growth.

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