Atorvastatin treatment is associated with increased BDNF level and improved functional recovery after atherothrombotic stroke

Abstract

Background: Statins have a positive impact on ischemic stroke outcome. It has been reported that statin have neuroprotective function after ischemic stroke in addition to lipid-lowering effect in animal model. However, the neuroprotective function of statin after stroke has not been confirmed in clinical studies. The aim of this study was to evaluate in a clinical model if statins induce neuroprotection after stroke. We, therefore, assessed serum brain-derived neurotrophic factor (BDNF) levels and functional recovery in atherothrombotic stroke patients and investigated their relationship with atorvastatin treatment. Methods: Seventy-eight patients with atherothrombotic stroke were enrolled and randomly assigned to atorvastatin treatment group or placebo control group. Neurological function after stroke was assessed with the National Institutes of Health Stroke Scale, modified Rankin Scale (mRS) and Barthel Index (BI). The serum BDNF levels were both measured at 1 day and 6 weeks after stroke. Linear regression was used to assess the association between BDNF levels and neurological function scores. Results: The mRS and BI were markedly improved in the atorvastatin group when compared to placebo at 6 weeks after stroke. The serum BDNF levels in atorvastatin group were significantly elevated by 6 weeks after stroke and higher than the BDNF levels in controls. In addition, the serum BDNF levels significantly correlated with mRS and BI after stroke. Our results demonstrated that atorvastatin treatment was associated with the increased BDNF level and improved functional recovery after atherothrombotic stroke. Conclusion: This study indicates that atorvastatin-related elevation in the BDNF level may promote functional recovery in stroke patients.

KEYWORDS:

• stroke
• BDNF
• atorvastatin
• NIHSS
• mRS
• BI

Acknowledgements

This study was financially supported by the National Natural Scientific Foundation of China [grant number: NSFC 330 81000534].

Declaration of Interest

The authors declare that there is no conflict of interests regarding the publication of this paper.

Additional information

Funding

National Natural Scientific Foundation of China [grant number: NSFC 330 81000534].