Paraoxonase and arylesterase activities in patients with papillary thyroid cancer

Abstract

Objective. The aim of this study was to evaluate paraoxonase-1 (PON1) activities and oxidative stress status, and the changes in their levels after total thyroidectomy in patients with papillary thyroid cancer (PTC). Materials and methods. Twenty-five patients with PTC and 27 healthy controls were enrolled in the study. Blood samples were obtained from the PTC patients before and 3 months after the operation. Preoperative and postoperative serum samples from PTC patients and healthy controls were analyzed for paraoxonase (PON), arylesterase (ARE) activities, and lipid hydroperoxide (LOOH) and –SH (total free sulfhydryl) levels. Results. The preoperative PON, ARE and –SH levels of the patients with PTC were significantly lower compared to those of the control group (p = 0.033, p < 0.001, p = 0.002, respectively), while LOOH levels were significantly higher (p < 0.001). The levels of PON and ARE decreased significantly in patients with PTC after the operation (p = 0.038, p = 0.023, respectively), while LOOH and –SH levels remained unchanged (p = 0.117, p = 0.487, respectively). PON and ARE levels showed a positive correlation with –SH (r = 0.211, p = 0.065; r = 0.471, p < 0.001, respectively) and a negative correlation with LOOH (r = − 0.391, p < 0.001, r = − 0.486, p < 0.001, respectively). Conclusion. Serum PON1 activity is decreased in patients with PTC, and serum PON1 is positively correlated with –SH, a well-known antioxidant, and negatively correlated with LOOH, an oxidant. PON1 activity is significantly decreased after total thyroidectomy.

Key Words::

• Arylesterase
• oxidative status
• papillary thyroid cancer
• paraoxonase

Declaration of interest: The authors report no conflict of interest. The authors alone are responsible for the content and writing of the paper.