Capillary Permeability in Human Skeletal Muscle Measured by Local Injection of ⁵¹Cr-EDTA and ¹³³Xe

Abstract

The skeletal muscle capillary permeability for ⁵¹Cr-EDTA, expressed as the Capillary Diffusion Capacity, CDCcr-EDTA' was measured in normal man after simultaneous injection of ⁵¹Cr-EDTA and ¹³³Xe into the anterior tibial muscle. During local hyperemia CDC_Cr-EDTA averaged 3.5, SD 0.7 moles/ 100g/min per mole/ml. Inhalation of carbon monoxide or local injection of histamine combined with local hyperemia did not influence the permeability significantly. In contrast local injection of hyaluronidase and hyperemia caused a highly significant increase in the permeability of the capillary wall.

Key Words:

• Capillary diffusion capacity
• carbon monoxide exposure
• free exercise
• histamine injection
• hyaluronidase injection
• increased capillary permeability
• radioisotopes
• reactive hyperemia