Gallbladder Sensitivity to Cholecystokinin in Coeliac Disease Correlation of Gallbladder Contraction with Plasma Cholecystokinin-like Immunoreactivity during Infusion of Cerulein

Abstract

The present study was undertaken to determine whether alterations in the gallbladder sensitivity to cholecystokinin (CCK), apart from a reduced endogenous CCK secretion, contribute to the abnormally decreased postprandial gallbladder contraction in patients with coeliac disease. Gallbladder emptying, measured by cholescintigraphy, and plasma CCK levels, measured by radioimmunoassay, were studied during infusion of graded doses of the CCK analog cerulein in six coeliac patients with subtotal villous atrophy, six coeliac patients on a gluten-free diet with normal villous architecture, and nine control subjects. Both in the patients and in the controls infusion of stepwise increasing doses of cerulein, in the range of 1-16 ng · kg⁻¹·h⁻¹, induced dose-related changes in plasma CCK-like immunoreactivity (CCK-LI) (r = 0.99; p < 0.001) and gallbladder emptying (r > 0.97; p < 0.01-p < 0.001). Plasma CCK-LI and gallbladder responses were not significantly different among untreated coeliac patients, treated coeliac patients, and controls. Gallbladder sensitivity to cerulein in untreated and treated coeliac patients was not significantly different from that in controls. It is concluded that the abnormally decreased gallbladder contraction in coeliac patients is the result of a reduced endogenous CCK secretion and not of a lack of end-organ responsiveness to CCK.

Key Words:

• Cholecystokinin
• coeliac disease
• gallbladder emptying