Percentages of CD4+ T regulatory cells and HLA-DR expressing monocytes in severe intra-abdominal infections

Abstract

To study the immune status of patients with severe abdominal infections, we assayed percentages of CD4+ T regulatory cells (CD4+CD25+FOXP3+ Treg) and human leukocyte antigen DR (HLA-DR) expressing CD14+ cells in peripheral blood. A total of 46 subjects with varying acute physiology and chronic health evaluation II (APACHE II) scores were included in the study. There was a significant (p < 0.01) increase in the percentage of CD4+CD25+FOXP3+ Treg and a significant (p < 0.01) decrease in HLA-DR expressing CD14+ cells with increasing APACHE II score. Such modifications may contribute to the aggravation of severe intra-abdominal infections.

Acknowledgements

Aspects of the work presented here were supported by grants from the State Administration of Traditional Chinese Medicine of the People's Republic of China and the Ministry of Science and Technology of the People's Republic of China. We thank Cui Naijie for guidance.

Declaration of interest: The authors have no financial conflict of interest, and none of the authors have a financial relationship with a commercial entity that has an interest in the subject of this manuscript.