Acute liver failure resulting from discontinuation of nucleoside analogues in chronic hepatitis B patients: A report of two cases

Abstract

Lamivudine, adefovir, telbivudine, and entecavir are nucleoside analogues that can inhibit hepatitis B virus replication and are licensed in China by the Food and Drug Administration. This study presents the cases of 2 patients who were chronically infected with HBV and suffered hepatic failure resulting from withdrawal of telbivudine and adefovir, respectively.

Keywords::

• Chronic hepatitis B
• nucleoside analogues
• pathological examination

Acknowledgements

We thank Prof. Qiurong Ruan who gave a precise and accurate description of the pathological sections.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.