Effects of Ginkgo biloba extracts on pharmacokinetics and efficacy of atorvastatin based on plasma indices

Abstract

1. Ginkgo biloba extract (GBE) is one of the most widely used herbal medicines in the world. It is often administered in combination with statins to treat diseases, especially some nervous system disorders. We aimed to investigate the influences of GBE on pharmacokinetics and efficacy of atorvastatin, which are currently unclear.

2. Sixteen volunteers received a single oral dose of 40 mg atorvastatin, followed by a wash-out period of at least 5 days. Then the volunteers took 360 mg GBE daily for 14 days, followed by a single dose of 40 mg atorvastatin. Serial blood samples obtained over a period of 48 h after atorvastatin ingestion were subjected to determination of atorvastatin plasma concentrations and markers of cholesterol synthesis (lathosterol) and cholesterol absorption (sitosterol).

3. With GBE administration, AUC_0–48, AUC_0–∞ and C_max of atorvastatin were reduced by 14.27% (p = 0.005), 10.00% (p = 0.03) and 28.93% (p = 0.002), respectively; Vd/F and CL/F of atorvastatin were increased by 31.95% (p = 0.017) and 6.48% (p = 0.044). After 14 days of treatment, GBE has no significant effects on cholesterol-lowering efficacy of atorvastatin.

4. This study suggests that GBE slightly decreases the plasma atorvastatin concentrations, but has no meaningful effect on the cholesterol-lowering efficacy of atorvastatin.

Keywords::

• Ginkgo biloba extract
• atorvastatin
• Alzheimer’s disease
• OATP1B1

Acknowledgment

We thank the study participants.

Declaration of interest

This work was supported by the National Scientific Foundation of China (No. 30801421, 30901834, 81001476, 81072706), Program for Changjiang Scholars and Innovative Research Team in University (IRT0946), Scientific Foundation of Hunan (No.11K073, 10JJ4020), 863 Project (No. 2009AA022710, 2009AA022703), NCET-10-0843.