Terpenoid biotransformation in mammals. V. Metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (−)-perillaldehyde, (−)-myrtenal, cuminaldehyde, thujone, and (±)-carvone in rabbits

Abstract

1. The metabolism of (+)-citronellal, (±)-7-hydroxycitronellal, citral, (-)-perill-aldehyde, (-)-myrtenal, cuminaldehyde, thujone, and (±)-carvone was studied in rabbits.

2. In (±)-7-hydroxycitronellal, (-)-perillaldehyde, (-)-myrtenal and cuminaldehydes, both primary alcohols and carboxylic acids were formed.

3. In (-)-citronellal and citral, regioselective oxidation was found and a trans-positioned methyl group was carboxylated in each case.

4. In o-cuminaldehyde, reduction but not oxidation, was found.