Maternal and fetal blood levels of S100 and ischaemia modified albumin in term intrauterine growth restricted fetuses with abnormal umbilical artery Doppler values

Abstract

The purpose of this study was to investigate whether levels of fetal hypoxia markers, S100 and ischaemia modified albumin (IMA) change in cases of intrauterine growth restriction (IUGR). This case–control study included 15 intrauterine growth restricted fetuses and 20 age-matched controls. During delivery of the fetuses, cord blood and maternal blood S100 and IMA levels were studied. The fetal weight and umbilical cord pH values of IUGR fetuses were significantly lower than the control group. The mean maternal and umbilical cord blood values of S100 and IMA were similar in the two groups. IMA levels in cord blood of the IUGR group were significantly higher than maternal levels, whereas umbilical and maternal levels of IMA did not differ among control cases. In cases without brain sparing effect in Doppler ultrasonography, umbilical cord S100 and IMA levels do not change significantly in IUGR when compared with appropriate-for-gestational-age (AGA) fetuses.

Keywords::

• Cord blood
• intrauterine growth restriction
• ischaemia modified albumin
• S100

Acknowledgements

The authors wish to thank all patients for their participation in this study, and all personnel at the Obstetrics and Gynecology Department for their enthusiastic contribution. E.D.O., H.O. and M.K. collected data, performed the analysis and the interpretation of data. G.S.C. also contributed to the acquisition of the data. Manuscript preparation was performed by G.S.C, M.K. and A.Y.G. Biochemistry specialists performing the biochemical analysis of the serum samples are R.T.S. and S.D. Drafting the manuscript or revising it critically for important intellectual content was performed by all authors. All authors have approved the final version of the manuscript.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.