The Effect of Autologous Serum Eye Drops on the Conjunctivalization over Exposed Porous Polyethylene Orbital Implant (Medpor^®) in the Rabbit Model

Abstract

Purpose: To assess the efficacy of autologous serum eye drops (AS) in enhancing conjunctivalization over a scleral patch graft on exposed porous polyethylene orbital implant (Medpor^®).

Methods: Eighteen rabbits were underwent evisceration, implantation of Medpor^® and homologous scleral patch graft. The conjunctival edge was sutured leaving 5 mm-diameter circular defect. In group A, 20% AS were applied 8 times a day and only balanced salt solution was applied in group B. Digital anterior segment photography was obtained 1, 3, 7, 10, 14, and 21 days after surgery and analyzed with Image Pro Plus^® software.

Results: In the early postoperative period, the average conjunctival growth rate (mm²/day) was faster in group A, but failed to show statistical significance (3.79 vs. 3.03, p = 0.26 in 1~3days, 2.39 vs. 1.80, p = 0.59 in 4–7days, 0.03 vs. -0.02, p = 0.94 in 7–10 days, Mann-Whitney test). The complete healing rate was higher (67% vs. 56%, p = 0.5, Fisher’s exact test) and the mean elapsed time for complete healing (days) was shorter in group A (17.3 vs. 18.2, p = 0.83, Mann-Whitney test), but did not show a statistically significant difference.

Conclusion: In a rabbit model, 20% AS did not appear to facilitate the healing of small conjunctival defects of exposed porous orbital implant.

Keywords::

• Autologous serum
• Conjunctiva
• Exposure
• Orbital implant

Declaration of interest: This research was supported by a grant from Seoul National University Hospital Research Fund. The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.