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Experimental Lung Research Volume 39, 2013 - Issue 2
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Research Article

Significant association of 5p15.33 (TERT–CLPTM1L genes) with lung cancer in Chinese Han population

Zhenhong ZhaoState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Cong LiCardiovascular Research Institute of Wuhan University, Wuhan, China
,
Lixin YangDepartment of Cardiothoracic Surgery and Pneumology, Changhai Hospital of Shanghai, Second Military Medical University, Shanghai, China
,
Xiaobo ZhangState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Xueying ZhaoState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Xiao SongState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Xiaoying LiState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Jiucun WangState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Ji QianState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Yajun YangState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Li JinState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, China
,
Hongyan ChenState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, ChinaCorrespondence[email protected] [email protected]
[email protected] [email protected]
&
Daru LuState Key Laboratory of Genetic Engineering and MOE Key Laboratory of Contemporary Anthropology, School of Life Sciences and Fudan Taizhou Institute of Health Sciences, Fudan University, Shanghai, ChinaCorrespondence[email protected] [email protected]
[email protected] [email protected]
 show all
Pages 91-98 | Received 11 May 2012, Accepted 21 Dec 2012, Published online: 31 Jan 2013
 
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ABSTRACT

Lung cancer is a leading cause of cancer-related deaths throughout the world. Recent genome-wide association studies and consecutive validation supported that the 5p15.33 region containing telomerase reverse transcriptase gene (TERT) and cleft lip and palate transmembrane protein 1-like (CLPTM1L) gene showed significant association with lung cancer in multiple populations. Here we studied a large Chinese Han cohort consisting of 1759 cases and 1804 controls. In the 1st stage (784 cases versus 782 controls) we genotyped 13 tag SNPs within 5p15.33 region to further investigate the association. After the 2nd stage validation (975 cases versus 1022 controls), the study clarified the association that rs2736100 of the TERT gene conferred the highest significant risk of lung cancer (P = 4 × 10−3 in the 1st stage association, P = 4 × 10−4 in the 2nd stage validation, and P = 1 × 10−5, odds ratio = 1.24 in the combined population). The results provided the evidence of a cross-race susceptibility of the lung cancer locus.

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