Fibronectin Glomerulopathy in a 34-year-old Man: A Case Report

Abstract

Fibronectin glomerulopathy is an inherited non-imune-mediated glomerulopathy associated with the massive deposition of fibronectin. It presents with proteinuria, microscopic hematuria, and hypertension that lead to end-stage renal failure in the second to sixth decade of life. A 34-year-old male was referred with proteinuria (6 g/day), microscopic hematuria and hypertension (220/130 mmHg). Renal biopsy specimen showed massive deposits of fibronectin in the mesangium and subendothelial spaces. After 20 months of multidrug treatment his renal function is stable.

Keywords:

• electron microscopy
• fibronectin
• glomerulopathy
• immunofluorescence
• proteinuria

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.