Encapsulating gold nanomaterials into size-controlled human serum albumin nanoparticles for cancer therapy platforms

Abstract

Progress has been made in using human serum albumin nanoparticles (HSAPs) as promising colloidal carrier systems for early detection and targeted treatment of cancer and other diseases. Despite this success, there is a current lack of multi-functional HSAP hybrids that offer combinational therapies. The size of the HSAPs has crucial importance on drug loading and in vivo performance and has previously been controlled via manipulation of pH and cross-linking parameters. Gold nanomaterials have also gained attention for medicinal use due to their ability to absorb near-infrared light, thus offering photothermal capabilities. In this study, the desolvation and cross-linking approach was employed to encapsulate gold nanorods, nanoparticles, and nanoshells into HSAPs. Incorporation of gold nanomaterials caused some changes in HSAP sizes, but the general size trends remained. This encasement strategy facilitated size-controlled HSAPs, in the range of 100–300 nm, loaded with gold nanostructures; providing composite particles which incorporate photothermally active components.

• Microencapsulation
• microsphere
• nanoparticle
• protein aggregation
• protein structure
• targeted drug delivery

Supplementary material available online

Supplementary Figures S1–S5.