Mass transport model through the skin by microencapsulation system

Abstract

Skin drug delivery can be subdivided into topical and transdermal administration. Transdermal administration can take advantage of chemical and physical strategies that can improve skin permeability and allow drug penetration. In this study, the development of a skin penetration profile was carried out by an in vitro technique for a microencapsulated system of ibuprofen. Release experiments were performed using percutaneous absorption tests to determine the evolution of the principle present in each of the different skin compartments as a function of time. A general kinetic model for a microencapsulated structure as a mass transport system through the skin was applied:

This model could predict the penetration profile of encapsulated substances through skin from biofunctional textiles as well as estimate the dosage profile of the active principle. The apparent diffusion coefficients found were 1.20 × 10⁻⁷cm/s for the stratum corneum and higher for the rest of the skin 6.67 × 10⁻⁶cm/s.

• Biofunctional textile
• ibuprofen
• in vitro skin delivery
• microencapsulation

Acknowledgement

The authors are indebted to the Skin Absorption Service (SAS-IQAC) for allowing the use of its laboratory.

Declaration of interest

The authors wish to thank the Spanish National Project (Ministerio de Educación y Ciencia) CTQ-PPQ2009-13967-C03-01 and the 2009 SGR 1212 (AGAUR) for providing financial support.