Central neurocytoma: A multi-disciplinary review

Abstract

Benign central neurocytoma (CN) is a rare neuronal tumour of the central nervous system recognised since the early eighties. More than 300 articles have been published in the literature, mostly comprising of case reports and short series from individual specialties. These tumours, though normally benign, are more often likely to recur after surgery than previously thought. A multi-modality team involvement, therefore, has become increasingly necessary for their optimum management. In this article, the authors from various neurosciences sub-specialties, with a specific interest and experience in managing CN, review the epidemiology, clinical features, pathological findings, radiological characteristics and surgical treatment, with an emphasis on the latest developments in their histology, molecular biology and adjuvant treatment modalities for recurrent or residual disease.

Key words:

• Central neurocytoma
• recurrent neurocytoma
• benign central neurocytoma
• intraventricular tumour
• brain tumour
• multimodality neuro-oncology management

Acknowledgements

The authors are grateful to Ms. Pamela Dougan, Research Assistant, Department of Radiology, Westmead Hospital, University of Sydney, Australia for her assistance in preparing the manuscript.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.