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British Journal of Neurosurgery Volume 24, 2010 - Issue 3
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Perioperative seizures following deep brain stimulation in patients with multiple sclerosis

Reuben D. JohnsonNuffield Department of Surgery, University of Oxford and Oxford Functional Neurosurgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UKCorrespondence[email protected]
,
Syed R. QadriNuffield Department of Surgery, University of Oxford and Oxford Functional Neurosurgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK
,
C. JointNuffield Department of Surgery, University of Oxford and Oxford Functional Neurosurgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK
,
L. MoirNuffield Department of Surgery, University of Oxford and Oxford Functional Neurosurgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK
,
A. L. GreenNuffield Department of Surgery, University of Oxford and Oxford Functional Neurosurgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK
&
T. Z. AzizNuffield Department of Surgery, University of Oxford and Oxford Functional Neurosurgery, John Radcliffe Hospital, Headley Way, Headington, Oxford, UK
Pages 304-305 | Received 29 Jul 2009, Accepted 20 Dec 2009, Published online: 14 May 2010
 
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Abstract

Following a total of 386 deep brain stimulation (DBS) procedures in Oxford, only two seizures have been recorded in the peri-operative period. Both patients had MS and underwent thalamic DBS for tremor and these 2 cases are presented here. The incidence of peri-operative seizures in MS patients undergoing DBS procedures is more than 8-fold greater than that expected for patients undergoing DBS procedures. Further experience with DBS procedures in MS patients is needed to determine whether there is a role for peri-operative anticonvulsants in these patients.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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