Candida parapsilosis meningitis associated with Gliadel (BCNU) wafer implants

Abstract

A 58-year old male presented with meningitis associated with subgaleal and subdural collections 6 weeks following a temporal craniotomy for resection of recurrent glioblastoma multiforme and Gliadel wafer implantation. Candida parapsilosis was cultured from cerebrospinal fluid (CSF) and Gliadel wafers removed during surgical debridement. He was successfully treated with liposomal amphotericin B. To our knowledge, this is the first reported case of Candida parapsilosis meningitis secondary to Gliadel wafer placement.

Key words:

• Candida parapsilosis
• Gliadel wafer
• glioblastoma multiforme
• postcraniotomy surgical site infection

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.