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British Journal of Neurosurgery Volume 25, 2011 - Issue 2
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Short Reports

Two cases of unexpected long-term improvement of Parkinson's disease after subthalamic nucleus deep brain stimulation removal

S. H. WongDepartments of NeurologyCorrespondence[email protected]
,
P. R. EldridgeNeurosurgery, The Walton Centre, Liverpool, UK
,
A. DuffyDepartments of Neurology
,
S. H. FoxMovement Disorders Clinic, University of Toronto, Toronto Western Hospital, Ontario, CanadaCorrespondence[email protected]
,
T. R. K. VarmaNeurosurgery, The Walton Centre, Liverpool, UK
&
N. A. FletcherDepartments of Neurology
Pages 281-283 | Received 02 Mar 2010, Accepted 06 Nov 2010, Published online: 23 Feb 2011
 
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Abstract

Two patients with Parkinson's disease (PD) treated successfully with subthalamic nucleus deep brain stimulation (STN-DBS) for 3–4 years are reported, who demonstrated a persistent improvement following removal of STN-DBS for late infection. Possible hypotheses are discussed – whether a microlesioning effect or a disease-modifying effect of STN-DBS, though neither adequately explain this phenomenon.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.

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