Prolonged survival associated with the use of intraoperative carmustine (Gliadel^®) in a paediatric patient with recurrent Grade III astrocytoma

Abstract

A 15-year-old female presented with a middle cranial fossa anaplastic astrocytoma that was completely excised. She received local radiotherapy (54 Gy) and oral temozolomide. Five months after therapy, MRI showed local relapse. She underwent resection of the tumour with implantation of seven carmustine-impregnated wafers (Gliadel^®). She then received six cycles of procarbazine and lomustine therapy. Three years later, she is well and disease free.

This case supports the further investigation of Gliadel^® in children and young people with relapsed high-grade glioma, particularly in the setting of a second complete resection.

Keywords::

• child
• Gliadel
• high-grade glioma
• relapse

Declaration of interest: The authors report no declarations of interest. The authors alone are responsible for the content and writing of the paper.