The Morfeo Study: A 1-year follow-up of complications of vegetative state in a dedicated facility

Abstract

Objectives: Vegetative State (VS) implies significant issues. The aim of the MORFEO study is to identify the most relevant complications in VS patients and to supply clinicians and policy-makers with data derived from the analysis of a cohort of patients treated in a dedicated long-term facility setting.

Methods: A cohort of 22 VS patients treated between 2003 and 2007 were enrolled and followed up for 1 year. The information recorded were: Disability Rating Scale (DRS), Levels of Cognitive Functioning (LCF), pressure sores, nutritional status, neurological complications, articular complications (passive range of motion–ROM), deep-vein thrombosis and infections. The Kolmogorov-Smirnov test was used to verify the normal distribution of the variables. The indicators of complications were analysed with the Friedman test (continuous variables) and with the Cochran Q test (dichotomous variables).

Results: DRS and LCF values showed no significant variation. The number of pressure sores decreased. The nutritional status remained satisfying. The ROM worsened in lower limb joints; a trend (p = ns) towards an improved range was observed in shoulders and elbows. Fifteen infections were recorded.

Conclusions: The data that proved significant suggest a minimum set of quality-of-care indicators in VS patients: pressure sores follow-up, nutritional status, ROM and incidence of infections.

• Vegetative state
• rehabilitation
• complications
• quality of life
• coma

Acknowledgements

Statistical analyses were conducted by Dr Elisa Carretta at the University of Bologna (Italy). The study was sponsored by Santa Viola Hospital – Bologna.

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.