Quality‐of‐life, mood and executive functioning after childhood craniopharyngioma treated with surgery and proton beam therapy

Abstract

Primary objective: Childhood craniopharyngioma, a benign tumour with a good survival rate, is associated with important neurocognitive and psychological morbidity, reducing quality‐of‐life (QoL).

Method: This retrospective study analysed QoL, mood disorders, everyday executive functioning and disease's impact on family life in 29 patients (mean age at diagnosis 7 years 10 months (SD = 4.1); mean follow‐up period 6 years 2 months (SD = 4.5)) treated for childhood craniopharyngioma by surgery combined with radiotherapy using proton beam. Assessment included a semi‐structured interview and standardized scales evaluating self‐report of QoL (Kidscreen 52) and depression (MDI‐C) and proxy‐reports of QoL (Kidscreen 52), executive functioning (BRIEF) and disease's impact (Hoare and Russel Questionnaire).

Results: Twenty‐three families answered the questionnaires completely. Overall QoL self‐report was within the normal range. QoL proxy‐report was lower than self‐report. Eleven patients reported depression; 24–38% had dysexecutive symptoms. A majority of families felt ‘very concerned’ by the disease. Depression and low parental educational level were associated with lower QoL and higher levels of executive dysfunction.

Conclusion: Given the high morbidity of childhood craniopharyngioma, screening for psychosocial outcome, cognitive functioning, including executive functions, mood and QoL should be systematic and specific interventions should be developed and implemented.

• Children
• quality‐of‐life
• community integration
• depression
• executive functioning
• outcome

Acknowledgements

This work was conducted by Doctor Christelle Laffond as part of the requirements for her medical thesis. It was partly funded by the Hôpital National de Saint Maurice. We thank Doctor Anne Laurent‐Vannier for her support. We also sincerely thank the patients and their families for participating in the study. We thank Associate Professor Cathy Catroppa for her help and advice and for the English corrections while preparing the manuscript and the reviewers for their valuable comments about the manuscript.

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.