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Abstract
Purpose: To examine the effect of topical doxycycline on human corneal neovascularization (CONV).
Materials and methods: Six eyes of six patients with CONV received topical 1% doxycycline four times per day for three weeks and monitored for a total of one year. Ophthalmic evaluations included visual acuity, tonometry, slit-lamp examination, conjunctival swabs, quantification of CONV and photography.
Results: CONV either disappeared or was attenuated, shortened and less dense in five of six patients. There were no adverse effects.
Conclusion: Topical doxycycline was effective in reducing CONV and healing of the ocular surface.