Characteristics of Children with Asthma Who Achieved Remissionof Asthma

Abstract

Objective. To characterize two groups of asthmatics who had achieved remission and those who had not achieved remission of asthma. Methods. The study was a retrospective cohort study based on 117 asthmatic children who participated in a previous study. We categorized the children into two groups: asthmatics with remission versus asthmatics without remission. We defined remission of asthma as lack of symptoms/signs of asthma or asthma-related medications or health care services for at least three consecutive years. Long-term remission was defined by no relapse of asthma after achieving remission. We characterized these groups. Results. Of the 117 subjects, 70 (60%) were male, 91 (78%) were Caucasians, and the mean age at index date of asthma was 8.1 years. A total of 59 asthmatic children (50%) achieved remission and 28 asthmatics (24%) achieved long-term remission. Asthmatics with remission were more likely to be Caucasian (87%) compared to those without (69%) (p = .039) There were no differences in the frequency of visits for viral (0.3 vs. 0.4 per person-years, p = .29) or bacterial infections (0.7 vs. 0.5 per person-years, p = .49) between asthmatics with and without remission. Gender, socioeconomic status, smoking exposure, family history of asthma or atopy, breastfeeding history, peak flow meter availability, asthma action plan, and influenza vaccinations were not associated with remission. Conclusions. Only half of asthmatic children accomplished remission of asthma ever and 24% of asthmatic children had long-term remission. Ethnicity may affect remission of asthma but microbial infections may not influence the likelihood of remission of asthma and vice versa.

• asthma
• childhood
• epidemiology
• microbial infection
• remission
• risk

Acknowledgments

The authors greatly appreciate the staff of the Pediatric Asthma Epidemiology Research Unit who made this study possible. The authors also thank Elizabeth Krusemark for administrative assistance

Declaration of Interest

The study investigators have nothing to disclose that poses a conflict of interest. The study was supported by the Clinician Scholarly Award from Mayo Foundation made possible by the the Rochester Epidemiology Project (R01-AG034676) from the National Institute of Aging.