Budesonide suspension nebulization treatment in Chinese pediatric patients with cough variant asthma: a multi-center observational study

Abstract

Objective: To describe the impact of nebulized budesonide inhalation suspension (BIS) on guardian-reported symptoms in Chinese pediatric patients with cough variant asthma (CVA).

Methods: This was a secondary analysis of a prospective, non-interventional study conducted at 39 Chinese sites. Patients with CVA aged ≤5 years were classified according to the severity of baseline symptoms: mild (symptom score ≤3) or severe (symptom score >3). Daytime and night-time symptom scores, disease control, use of bronchodilators, and improvements in symptoms control were compared after 1, 3, 5 and 7 weeks of treatment between groups. Results: Among 914 patients, 821 (89.8%) completed the 7-week treatment. Among all patients, 368 (40.3%) were classified as mild CVA and 529 (57.9%), as severe CVA. Symptom scores in the severe group were higher than those in the mild group at weeks 1, 3, and 5 (p < 0.05), but not at week 7 (p > 0.05). Further, more patients in the mild group achieved disease control at any time point (98.6% at 3 weeks and 99.7% at 7 weeks), compared with the patients in the severe group (p < 0.001). The proportion of patients requiring bronchodilators differed between the groups until week 5 (p < 0.001). No severe or drug-related adverse events were reported. Conclusions: Individualized BIS treatment should be formulated according to the severity of baseline symptoms in CVA patients. Patients with mild CVA showed improvement after a shorter treatment time, while patients with severe CVA might require a longer time to respond to the treatment.

• Baseline symptoms
• budesonide suspension nebulization treatment
• cough variant asthma

Acknowledgements

The study was funded by AstraZeneca. The authors would like to thank Dr Ramu Periyasamy (Indegene Lifesystems Pvt Ltd, Bangalore, India) for assisting the authors in revising this manuscript, funded by AstraZeneca. We thank the investigators of the 39 sites for their substantial support (sorted alphabetically): AN Su-ying (The Second Hospital of Hebei Medical University); CHEN Qiang (Children’s Hospital of Jiangxi Province); CHEN Zhi-min (The Children’s Hospital, Zhejiang University School of Medicine,); CHENG Bao-jin (Changzhou No.2 People’s Hospital); CHENG Huan-ji (The First Affiliated Hospital of Jilin University); FANG Hong (Tongji Hospital, Tongji Medical College of Tongji Medical College Huazhong University of Science and Technology); HAN Yu-ling (Jinan Children’s Hospital); HAN Zhi-ying (Shanxi Maternal & Child Healthcare Hospital); HE Shao-ru (Guangdong People’s Hospital); HONG Jian-guo (The First Affiliated People’s Hospital of Shanghai Jiaotong University); HU Ying-hui (Beijing Children’s Hospital); HU Yue (Shenyang Children’s Hospital); HUANG Xian-mei (Hangzhou First People’s Hospital); HUANG Ying (Children’s Hospital of Chongqing Medical University); LI Chang-chong (The Second Affiliated Hospital & Yuying Children’s Hospital of Wenzhou Medical University); LI Guo-rong (Ningbo Women & Children’s Hospital); LI Li (First People’s Hospital of Yunnan Province); LI Min (Sichuan Provincial People’s Hospital); LI Xin-min (First Teaching Hospital of Tianjin University of TCM); LI Yun (Hunan Provincial People’s Hospital); LIANG Kun (First Affiliated Hospital of Kunming Medical University); LIN Rong-jun (The Affiliated Hospital of Qingdao University); LIU Xiao-hong (The First Affiliated Hospital of Xi’an Jiaotong University); LIU Yu-ling (Boai Hospital of Zhongshan); PAN Jia-hua (Anhui Provincial Hospital); SHENG Jin-yun (Soochow University Affiliated Children’s Hospital,); SUN Guang-rong (Qingdao Women and Children Medical Healthcare Center); TAN Wei-ping (Second Affiliated Hospital of Sun Yat-Sen University); WANG Li-bo (Children’s Hospital of Fudan University); WANG Xiu-fang (Third Affiliated Hospital of Zhengzhou University); WU Jin-zhun (The First Affiliated Hospital of Xiamen); XIE Juan-juan (Wuxi People’s Hospital); YANG Jian-zhi (Quanzhou Women’s and Children’s Hospital); YAO Li (The Second Affiliated Hospital of Harbin Medical University); ZHANG Guo-zhong (Ruian People’s Hospital); ZHAO De-yu (Nanjing Children’s Hospital); ZHEN Yue-jie (Shenzhen Children’s Hospital); ZHOU Wei (Peking University Third Hospital); ZHOU Xiao-qin (Hubei Women & Children’s Health Hospital).

Declaration of interest

The authors declare that they have no any conflict of interests.