Risk factors for diabetes, but not for cardiovascular disease, are associated with family history of Type 2 diabetes in subjects from central Mexico

Abstract

Background: Independent of obesity, family history of type 2 diabetes mellitus (FHT2DM) is another important risk factor for developing diabetes.

Aim: To establish the association among FHT2DM, risk factors for diabetes and cardiovascular disease in subjects from central Mexico.

Subjects and methods: Clinical and biochemical studies were performed in 383 first-degree relatives of patients with type 2 diabetes and 270 subjects unrelated to patients with type 2 diabetes—all subjects were from the city of Puebla in central Mexico. Logistic regressions were used to assess the association between FHT2DM and metabolic parameters. Cardiovascular risk was classified by dyslipidemia and the Framingham Risk Score (FRS).

Results: FHT2DM was associated with risk factors for diabetes, such as increased fasting insulin levels (OR = 1.731, 95% CI = 1.041–2.877), decreased insulin sensitivity (OR = 1.951, 95% CI = 1.236–3.080) and pre-diabetes (OR = 1.63, 95% CI = 1.14–2.33). FHT2DH was not associated with risk factors for cardiovascular disease, such as dyslipidemia (OR = 1.12, 95% CI = 0.70–1.79) and FRS (OR = 0.74, 95% CI = 0.40–1.36) when adjusted for gender, age, smoking and obesity.

Conclusion: Diabetic risk factors, but not cardiovascular disease risk factors, are associated with a positive family history of diabetes in subjects from central Mexico, independent of the presence of obesity.

Keywords::

• Diabetes risk factors
• cardiovascular disease risk factors
• first-degree relatives of type 2 diabetic patients
• subjects from central Mexico

Acknowledgements

The Multidisciplinary Research Group on Diabetes was made up of Fernando Guerrero-Romero, PhD, Martha Rodríguez-Morán, PhD, Silvia Flores-Martínez, PhD, José Sánchez-Corona, PhD, Sergio A. Islas-Andrade, PhD, Esperanza Martínez-Abundis, PhD, Manuel González-Ortiz, PhD, Agustín Madero, PhD, and Jorge Escobedo-de la Peña, MSc.

This study was supported by grants from the Consejo Nacional de Ciencia y Tecnología de México, SALUD 2004-01-023, Fundación IMSS, A.C. IZ-G was supported by grants from Consejo Nacional de Ciencia y Tecnología de México, CVU/Becario 165584.

We gratefully acknowledge the commitment and dedication of physicians, chemists, nurses and participating personnel in the Mexican Diabetes Prevention Study. The manuscript was edited by M. Elba Gonzalez-Mejia and Leonardo M. Porchia.

Declaration of Interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.