Power of biomarkers and their relative contributions to metabolic syndrome in Slovak adult women

Abstract

Background: Metabolic syndrome (MetS) comprises a cluster of risk components which pre-dispose individuals to cardiovascular mortality.

Aim: The purpose of this study is to investigate the variability of biochemical and anthropometric characteristics, apolipoprotein E (APOE) and angiotensin converting enzyme (ACE) genes and their contribution to MetS manifestation.

Subjects and methods: A total of 438 adult women were recruited from different localities in Slovakia. All data was established by standard anthropometric, biochemical and genetic methods.

Results: The logarithm of the ratio of plasma concentration of triglycerides to HDL-cholesterol [log(TG-to-HDL-C)], waist circumference, systolic blood pressure, apolipoprotein A1, glucose and alanin aminotransferase accounted for most of the differences in MetS manifestation. Logistic regression showed that participants with risk values of the atherogenic index log(TG-to-HDL-C) had a 15.62-fold higher risk of MetS compared to those with lower values for this index (95% CI = 8.3–29.1). Women with hyperglycaemia (or formerly diagnosed diabetes mellitus) had an 8.82–times higher risk of MetS (95%CI = 3.22–24.16). Women with hyper-uricaemia had the same risk of MetS incidence as women with abdominal obesity, Exp (B) = 4.05.Hypercholesterolaemia, ACE and APOE genotypes did not influence MetS.

Conclusion: MetS may involve many risk factors that can cause serious disorders in multiple organs. However, women with risk values involving plasma atherogenic index log (TG-to-HDL-C) experienced the highest risk of developing MetS.

Keywords::

• Metabolic syndrome
• biochemical parameters
• APOE genotypes
• ACE genotypes

Acknowledgements

This study was supported by the Scientific Grant Agency of the Ministry of Education, Science, Rresearch and Sport of the Slovak Republic and the Slovak Academy of Sciences (VEGA) (1/3284/06, 1/0247/09) and by the Grant of Comenius University in Bratislava (UK/227/2011).

Declaration of interest : The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.