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Hemoglobin
international journal for hemoglobin research
Volume 35, 2011 - Issue 2
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Short Communication

Identification of a New α Chain Variant at Codons 22–25 (–9 nts) Using the Sebia Capillarys 2 Electrophoresis System

Can Liao Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Jian-Ying Zhou Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Xing-Mei Xie Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Ying-Na Liu Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
,
Li-He Chen Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of China
&
Dong-Zhi Li Prenatal Diagnostic Center, Guangzhou Maternal & Neonatal Hospital, Guangzhou Women & Children Medical Center, Guangzhou Medical College, Guangzhou, Guangdong, People's Republic of ChinaCorrespondence[email protected]
Pages 166-170 | Received 27 Nov 2010, Accepted 02 Dec 2010, Published online: 21 Mar 2011
 
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Abstract

We have identified a new α chain hemoglobin (Hb) variant in a Chinese family. Sequencing of the amplified α2-globin gene revealed a 9 nucleotide (nt) deletion (–C GAG TAT GG) at codons 22–25, which results in a predicted α-globin chain that is missing amino acid residues 23–25 (Glu-Tyr-Gly) and the formation of Hb Zhanjiang.

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