Spectrum of Common α-Globin Deletion Mutations in the Southern Region of Vietnam

Abstract

The common deletion mutations of α-globin genes in the Vietnamese population is not well known. Here we report the presence of five deletional mutations of Southeast Asia in the southern region of Vietnam. The – –^SEA (NG_000006.1: g.26264_45564del19301) mutation is the most common type of deletion (87.35%), followed by the –α^3.7 (rightward) (NG_000006.1: g.34164_37967del3804) deletion (9.64%), –α^4.2 (leftward) (AF221717) deletion (2.41%) and – –^THAI (NG_000006.1: g.10664_44164del33501) (0.6%) mutation in this region. The – –^FIL (NG_000006.1: g.11684_43534del31581) mutation was not detected in this study. This result provided a view of the distribution of common α-globin gene mutations in Vietnam and could serve as a baseline for further investigations into these genetic defects.

• α-Globin genes
• α-thalassemia (α-thal)
• Vietnam

Declaration of interest

The authors report no conflicts of interest. The authors alone are responsible for the content and writing of this article.