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Drug Development and Industrial Pharmacy Volume 37, 2011 - Issue 5
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Original Article

Relationship between critical relative humidity and solubility of drugs

Yingli WangKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China
,
Xiancheng ZhanKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. ChinaCorrespondence[email protected]
,
Lin LuoKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China
,
Jia ChenKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China
,
Chaoqun XiangKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China
,
Chengrong LiKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China
&
Linli LiKey Laboratory of Drug Targeting, West China School of Pharmacy, Sichuan University, Chengdu, Sichuan 610041, P. R. China
 show all
Pages 547-551 | Received 25 Jul 2010, Accepted 27 Sep 2010, Published online: 03 Dec 2010
 
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Abstract

Both the critical relative humidity (Hcr) and the solubility are important physicochemical properties that affect the quality of drugs. However, the relationship between them is not noticed yet. By an analysis of interaction between molecules of drug and water, the conclusion logically obtained is: the higher the solubility is, the lower the Hcr will be. To validate this idea, the Hcr and the solubility of 33 drugs and chemicals were determined and a negative linear correlation was found between the two factors when the solubility was expressed as the mole fraction of water. This negative linear correlation was further confirmed by a computer simulation according to modified Debye-Hückel equation.

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