Effect of textured eye drop bottles on the photostability of pranoprofen 0.1% ophthalmic solution

Abstract

Context: Ophthalmic solutions are usually filled in a plastic bottle due to its durability and disposability. In Japan, photostability is one of the concerns for the quality control because an eye drop bottle must be a transparent container.

Objective: The present work studied the effect of textured eye drop bottles on its light blocking to improve the photostability of ophthalmic solutions.

Materials and methods: We investigated the photostability of Pranoprofen ophthalmic solution filled in a variety of textured eye drop bottles. Pranoprofen content was analyzed by high-performance liquid chromatography and surface structure of textured eye drop bottles was evaluated by transmittance, calculated average roughness (Ra) and haze intensity.

Results: We observed that eye drop bottle which had greater than Ra value of 1.0 µm and haze intensity 62% clearly showed photostability improvement.

Conclusions: This report is the first one which shows that photostability of ophthalmic solution is improved by using textured eye drop bottle. Moreover, this approach is a simple and effective method to improve the photostability. This method is available for not only various ophthalmic applications but also other liquid pharmaceuticals or food products.

• Eye drop bottle
• haze
• ophthalmic solution
• photostability
• pranoprofen
• Ra
• textured surface

Acknowledgements

We thank Dr. Tapan Shah for his helpful advice and cooperation.

Declaration of interest

The authors indicate no financial support or financial conflict of interest related to this article.