Evaluation of Defatted Soybean Flakes as a Tablet Excipient Part I. As a Disintegrant

Abstract

Oriental people have been using soybeans as a protein foodstuff for centuries. At present soybeans have become a major source of edible oil, and the meal provides an important source of protein for animal feeds. In the present study, the dehulled, and defatted soybean flakes were investigated as a possible tablet excipient.

Four different samples (sieve fraction 150-180 um), namely samples A, B, C, and D were prepared from dehulled, defatted soybean flakes and their physical characteristics were determined subsequently. Compacts of these four substances and their binary mixtures with dicalcium phosphate dihydrate in four different ratios were also prepared at seven different compression pressures.

The changes in density of the compacts under compression were 1 2 interpreted using the Heckel plots ^{1, 2} The crushing strength and disintegration time of the subsequent compacts were also determined. Great differences in the disintegrating properties between the four soybean samples were noticed.

Samples A, B, C, and D, corn starch, microcrystalline cellulose and starch 1500 were added to dicalcium phosphate dihydrate either as intragranular, extragranular or both intra- and extragranular disintegrants respectively; the compacts of these substances were prepared at two compression pressures and the disintegration time of the compacts determined. In general the disintegrating efficiencies are in the rank order corn starch>starch 1500>sample Osample D>sample B>sample A>microcrystalline cellulose.