Evaluation of Compression Behavior of Paracetamol Tablets Produced with β Cyclodextrin Dispersions. Part II: Energy Distribution Study of Tablets

Abstract

The compression behavior of three paracetamol/β-cyclodextrin solid dispersions (PAR/β-CD, ratio 1: 1 w/w), which differ in particle size, shape, and crystallinity, were studied using force-displacement measurements (F-D plots). The measured parameters included: effective work, expansion work, friction work, useful work, and plasticity derived from F-D plots at the tableting stage. The PAR/β-CD spray-dried solid dispersion has the best compressional behavior, compared to other dispersions (PAR/β-CD physical mixture and PAR/β-CD kneaded solid dispersion) and PAR alone. Energy distribution study also showed that β-CD has positive influence on the PAR compression characteristics.