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Cancer Investigation Volume 28, 2009 - Issue 2
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ORIGINAL ARTICLESCellular and Molecular Biology

Nuclear Factor-Kappa B Inhibition Reduces Markedly Cell Proliferation in Epstein-Barr Virus-Infected Stomach Cancer, But Affects Variably in Epstein-Barr Virus-Negative Stomach Cancer

Jin-Yong JeongCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Jun Hee WooCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Yang Soo KimCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Sangho ChoiCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Sang Oh LeeCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Seol-Ryoung KilCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
,
Chul Woo KimCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Byung Lan LeeCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Woo Ho KimCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Byung-Ho NamCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
&
Mee Soo ChangCenter for Antimicrobial Resistance and Microbial Genetics, Department of Infectious Diseases, Department of Preventive Medicine, Asan Medical Center and Asan Institute for Life Sciences, University of Ulsan College of Medicine, Seoul 138-736, Korea, Department of Pathology, Cancer Research Institute, Department of Anatomy, Seoul National University College of Medicine, Seoul 110-799, Korea, Cancer Biostatistics Branch, Center for Clinical Trials, National Cancer Center, Goyang-si, Gyeonggi-do, 410-769, Korea, and Department of Pathology, Seoul National University Boramae Hospital, Seoul 156-707, Korea
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Pages 113-119 | Published online: 07 Dec 2009
 
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ABSTRACT

Nuclear factor-kappa B (NF-κB) inhibition by NF-κB p65-specific siRNA induced a near-cessation of cell proliferation in EBV-positive stomach cancer cell, and notably diminished cell proliferation in EBV- positive Raji lymphoma cell. In EBV-negative stomach cancer cells, NF-κB inhibition affected variably cell proliferation. Regardless of cell type, NF-κB inhibition suppressed antiapoptotic function of NF-κB, and tended to promote the nuclear accumulation of beta-catenin. This inverse relationship between NF-κB and beta-catenin was evident in 120 resected gastric carcinomas. Conclusively, NF-κB inhibition may be beneficial in the therapy of EBV-positive stomach cancer, but influence variously EBV-negative stomach cancer.

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