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Cancer Investigation Volume 28, 2009 - Issue 2
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ORIGINAL ARTICLESCellular and Molecular Biology

Focal Adhesion Plaque Associated Cytoskeletons Are Involved in the Invasion and Metastasis of Human Colorectal Carcinoma

Hong-Jun YangDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, and Key Laboratory of Molecular Tumor Pathology of Guangdong Province, Guangzhou, China
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Juan-Zhi ChenDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, and Key Laboratory of Molecular Tumor Pathology of Guangdong Province, Guangzhou, China
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Wen-Li ZhangDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, and Key Laboratory of Molecular Tumor Pathology of Guangdong Province, Guangzhou, China
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Yan-Qing DingDepartment of Pathology, School of Basic Medical Sciences, Southern Medical University, Guangzhou, China, Department of Pathology, Nanfang Hospital, Southern Medical University, Guangzhou, China, and Key Laboratory of Molecular Tumor Pathology of Guangdong Province, Guangzhou, China
Pages 127-134 | Published online: 16 Nov 2009
 
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ABSTRACT

The protein and mRNA expression of focal adhesion plaque associated cytoskeletons, including talin, vinculin, paxillin, and tensin, was studied using immunofluorescence in combination with confocal laser scanning microscopy and fluorescent quantitative polymerase chain reaction in 41 matched samples of human normal colorectal mucosae, primary colorectal adenocarcinomas, and 19 separate lymph node metastases. All specimens showed expression. The results showed talin, vinculin, tensin, and paxillin expression were correlated with carcinogenesis, invasion, and metastasis of colorectal carcinoma (CRC). Talin, vinculin, and tensin underwent downregulation while paxillin went up. So these cytoskeletons may play bidirectional regulating roles during the progression of CRC.

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