Advanced search
Publication Cover
Cancer Investigation Volume 28, 2010 - Issue 8
Submit an article Journal homepage
54
Views
8
CrossRef citations to date
0
Altmetric
ORIGINAL ARTICLECellular and Molecular Biology

Manganese Superoxide Dismutase Expression as a Function of Genotype and Lung Cancer Pathology

Robert C. G. MartinDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USACorrespondence[email protected]
,
Yan LiDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA
,
Qiahong LiuDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA
,
David F. BarkerDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA
,
Mark A. DollDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA
&
David W. HeinDepartments of Surgery, James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA,and Pharmacology & Toxicology,James Graham Brown Cancer Center, University of Louisville School of Medicine, Louisville, Kentucky, USA
Pages 813-819 | Published online: 06 Aug 2010
 
Sample our Medicine, Dentistry, Nursing & Allied Health journals, sign in here to start your FREE access for 14 days

ABSTRACT

Introduction: The aim of this study was to compare the manganese superoxide dismutase (MnSOD) expression in matched tumor and normal tissue. Methods: One hundred lung cancer specimens and matched normal lung parenchyma from the same patient were evaluated for MnSOD expression. Results: The median normal MnSOD expression was 42% with a range of 10 to 70%, which was significantly greater (p = .001) than the median MnSOD expression in the tumor samples that was 18.8% and ranged from 1.1 to 50%. Conclusion: MnSOD expression is significantly reduced in lung adenocarcinoma and squamous cell carcinoma compared to the matched normal lung tissue.

Log in via your institution

Access through your institution

Log in to Taylor & Francis Online

Restore content access

Restore content access for purchases made as guest
Purchase options * Save for later

PDF download + Online access

  • 48 hours access to article PDF & online version
  • Article PDF can be downloaded
  • Article PDF can be printed
USD 65.00 Add to cart

Issue Purchase

  • 30 days online access to complete issue
  • Article PDFs can be downloaded
  • Article PDFs can be printed
USD 1,193.00 Add to cart

* Local tax will be added as applicable

Related Research

People also read lists articles that other readers of this article have read.

Recommended articles lists articles that we recommend and is powered by our AI driven recommendation engine.

Cited by lists all citing articles based on Crossref citations.
Articles with the Crossref icon will open in a new tab.