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Cancer Investigation Volume 28, 2010 - Issue 8
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ORIGINAL ARTICLEClinical Translational Therapeutics

Weekly Chemotherapy with Cisplatin and Paclitaxel and Concurrent Radiation Therapy as Preoperative Treatment in Locally Advanced Esophageal Cancer: A Phase II Study

Michele OrdituraDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Gennaro GaliziaDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Vincenzo NapolitanoDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Erika MartinelliDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Roberto PacelliDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Eva LietoDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Gaetano AurilioDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Loredana VecchioneDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Floriana MorgilloDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Giuseppe CatalanoDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Fortunato CiardielloDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Alberto Del GenioDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
,
Natale Di MartinoDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
&
Ferdinando De VitaDivision of Medical Oncology, Division of Surgical Oncology, Department of Clinical and Experimental Medicine and Surgery “F. Magrassi e A. Lanzara”, Second University of Naples, School of Medicine, Naples, Italy, Division of Radiotherapy, Federico II University of Naples, School of Medicine, Naples, Italy
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Pages 820-827 | Published online: 18 May 2010
 
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ABSTRACT

We evaluated the association of a weekly cisplatin (35 mg/mq) and paclitaxel (45 mg/mq) regimen with radiotherapy (46 Gy) as primary treatment in locally advanced esophageal cancer (LAEC). The main end point was the activity in terms of pathologic complete response (pathCR) rate. Thirty-three LAEC patients received chemoradiation therapy during weeks 1–6 followed by esophagectomy. A pathCR was observed in 10/33 patients; 20/33 and 3/33 patients showed PR and SD, respectively. The EUS maximal transverse cross sectional area reduction >50% significantly correlated with pathCR. Three-year survival rate was 35%. These results support the activity and mild toxicity of this regimen.

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