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Cancer Investigation Volume 28, 2010 - Issue 6
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ORIGINAL ARTICLEClinical Translational Therapeutics

Overcoming Drug Resistance in Mantle Cell Lymphoma Using a Combination of Dose-Dense and Intense Therapy

Christopher A. CroutDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Liang-Piu KohDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Jon P. GockermanDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Joseph O. MooreDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Carlos DeCastroDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Gwynn D. LongDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Louis DiehlDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Christina GasparettoDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Donna NiedzwieckiDepartment of Biostatistics and Bioinformatics, Duke University Medical Center, Durham, NC, USA,
,
Jon EdwardsDuke Oncology Consortium, Walt Disney Cancer Center, Orlando, FL, USA,
,
Leonard ProsnitzDuke University Medical Center, Department of Radiation Oncology, Durham, NC, USA,
,
Mitchell HorwitzDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Jon ChuteDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Ashley MorrisDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Patricia DavisDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Anne BeavenDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Nelson J. ChaoDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
,
Francis Ali-OsmanDuke University Medical Center, Department of Surgery and the Comprehensive Cancer Center, Durham, NC, USA
&
David A. RizzieriDuke University Medical Center, Department of Medicine, Division of Oncology and Stem Cell Transplantation, Adult Bone Marrow Transplantation Program, Durham, NC, USA,
 show all
Pages 654-660 | Published online: 03 Jun 2010
 
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ABSTRACT

We present a study of the prevalence of genetic polymorphisms and expression of genes encoding the drug-resistance proteins glutathione S-transferases (GSTs) in order to gain insights into the pattern of failure evident in mantle cell lymphoma. We note a high preponderance of genetic alterations conferring resistance to standard chemotherapy in this illness. Concurrent with this investigation, we present a series of patients who were provided dose-dense and intense chemotherapy to circumvent these drug-resistance mechanisms. High responses were noted, though durable remissions were few, indicating non-traditional chemotherapy options are important to investigate in this illness.

ACKNOWLEDGMENTS

We thank the nurses and referring physicians for their care of these patients.

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