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Cancer Investigation Volume 28, 2010 - Issue 6
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ORIGINAL ARTICLEClinical Translational Therapeutics

The Role of Matrix Metalloproteinase 2 on the Survival of Patients with Non-Small Cell Lung Cancer: A Systematic Review with Meta-Analysis

Qian QianDepartment of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China,
,
Qian WangDepartment of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China,
,
Ping ZhanDepartment of Respiratory Medicine, Nanjing Chest Hospital, Nanjing 210029, China,
,
Ling PengDepartment of Medical Oncology, Jinling Hospital, 305 East Zhongshan Road, Nanjing 210002, China
,
Shu-Zhen WeiDepartment of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China,
,
Yi ShiDepartment of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China,
&
Yong SongDepartment of Respiratory Medicine, Jinling Hospital, Nanjing University School of Medicine, 305 East Zhongshan Road, Nanjing 210002, China,
 show all
Pages 661-669 | Published online: 15 Apr 2010
 
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ABSTRACT

To evaluate the prognostic value of Matrix Metalloproteinase2 (MMP-2) expression in patients with non-small cell lung cancer (NSCLC), the electronic database PubMed, EMBASE were searched for relevant articles. The meta-analysis was finally based on 11 studies that included 1,439 patients, and combined HR was 1.66 (95% confidence intervals (CI: 1.37–2.01). Its effect also appeared significant when the analysis was restricted to tumor cell expression and patients with adenocarcinoma (HR 2.08 (95% CI: 1.24–3.48)). This study supported the fact that MMP-2 could be included in further prospective trials studying prognostic factors in NSCLC.

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