Pigment Epithelium-Derived Factor Expression in Colorectal Cancer Patients

ABSTRACT

Pigment epithelium-derived factor (PEDF) is a potent inhibitor of angiogenesis and has been proposed to be a tumor suppressor in a variety of tumors. Limited reports exist of PEDF in colorectal cancer (CRC). We noted a 55% lower plasma level (p < .001) of PEDF in the CRC patient group (1.6 μg/mL) than in of a healthy control group (3.6 μg/mL). A single nucleotide polymorphism (rs1136287, T>C) was screened. In the control group, the CC genotype showed 30% lower PEDF plasma levels compared with the TT genotype (p < .01), whereas the CRC patients failed to show any association regarding these genotypes.

Keywords: :

• Pigment epithelium-derived factor
• Polymorphism
• Protein expression
• Colorectal cancer

ACKNOWLEDGMENT

The authors thank Karin Ström (Ryhov County Hospital, Jönköping, Sweden) for excellent technical support. This work was supported by grants from Futurum –(the academy of health care), County Council of Jönköping (Sweden), the Foundation of Clinical Cancer Research (Jönköping, Sweden), and the University College of Health Sciences (Jönköping, Sweden).

Declaration of interest: The authors report no conflicts of interest. The authors alone are responsible for the content and writing of the paper.